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VIP exerts its effects by binding to specific G-protein coupled receptors, notably VPAC1 and VPAC2 receptors, which are present in various tissues including the brain, gastrointestinal tract, and immune system [3]

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This imbalance can result in an excess of reactive oxygen species (ROS), which then overwhelms the bodys antioxidant defences, resulting in oxidative stress

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Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: insights from the DCCT/EDIC study