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The article names a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, diabetic retinopathy requiring treatment, and severe gastrointestinal disease as situations demanding careful medical evaluation before initiation

This risk is based on observations in rodent studies, but a causal relationship in humans has not been established

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Randomisation of patients was done to once-daily semaglutide, liraglutide, or placebo as 2:2:1 in one of four volume-matched doses (Both semaglutide 0.05, 0.1, 0.2, or 0.3 mg and liraglutide 0.3, 0.6, 1.2, or 1.8 mg, within each volume-matched dose group were compared)