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as excess energy accumulates, white adipose tissue (WAT) cells undergo abnormal, hypertrophic growth, leading to poor blood supply (hypoxia), macrophage infiltration, and systemic inflammation

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Regular intake of vegetables rich in fibre and fruits can be considered for prevention on a regular, long-term basis

The intricate structural and biochemical interactions between skeletal muscle and the vascular endothelium facilitate optimal nutrient and oxygen transport, the clearance of metabolic byproducts, and the release of myokines and vasculokines that mutually regulate their respective functions (3, 4)

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