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Pipe tobacco tends to be a blend of tobacco types roughly cut into thicker strips when compared to hand-rolling tobacco

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A land use mix measure (factor 3) was calculated based on entropy [66] following an approach described by Donnellan [67], whereby land use zoning data provided by councils were re-classified into the following six categories: commercial, residential, retail/industrial, institutional, open space, and other (e.g., vacant land)

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Cross-sectional analyses using US and Korean survey data have reported increased odds of hypertension among exclusive e-cigarette users [19,20,21], although a prospective analysis of the All of Us Research Program found no significant association in the main analysis [22]