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Gohel 2009

Enhances brain-derived neurotrophic factor pathways, supporting neuronal growth, dendritic spine formation, long-term potentiation, and synaptic plasticity necessary for memory consolidation and cognitive function

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By disrupting this interaction, FOXO4-DRI allows p53 to trigger apoptosis in senescent cells while sparing normal cells making it a research tool for selective senolysis

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