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Selank (synthetic Tuftsin analogue) modulates GABA-A receptors as a positive allosteric modulator and inhibits enkephalin degradation, creating anxiolysis and cortisol suppression without sedation

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doi: 10.1136/annrheumdis-2012-202460

Peptide therapy has recently gone mainstream thanks to popular peptides like semaglutide (Ozempic) and tirzepatide (Mounjaro)

Unfortunately, several treatments, though successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events, as reviewed (60)