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In vitro experiments revealed that liensinine could alleviate ferritinophagy and inhibit ferrous iron release and lipid peroxidation to boost AAMs resistance to ferroptosis, potentially by blocking the autophagosome-lysosome fusion and subsequently inhibiting the recruitment of ferritin into the lysosomes for degradation (85)

doi: 10.4161/gmic.2.5.18255 99 HugotJPChamaillardMZoualiHLesageSCzardJPBelaicheJet al

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This phenomenon reflects that, under condition of iron overload, autophagy might undergo compensatory inhibition to limit further iron release and ferroptosis (82)

Beneficial effect of probiotics in ibd: are peptidogycan and nod2 the molecular key effectors