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In the pilocarpine-induced seizure model, the density of microglial cells thus contributes to decreasing the seizure threshold and compromising neuronal survival (Vezzani et al., 2008

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It met its primary endpoint, with a statistically significant improvement in pain with Xiaflex versus placebo, as measured by the Average Daily Pain Intensity on the Numeric Rating Scale (NRS), which Keenova said was a "clinically meaningful" result