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Future perspectives in terms of nephro-protection in lupus nephritis Finerenone Novel MRA, like finerenone, are known to block MR-mediated sodium reabsorption and MR overactivation with additionally demonstrated anti-inflammatory and anti-fibrotic effects ( SGLT2i Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have recently been demonstrated to exert profound cardio and nephroprotection in large cardiovascular outcome trials ( via a glucose-independent hemodynamic mechanism

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Obese mice exhibited lower baseline expression of 3-AR in both fat types compared to lean controls