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One factor that may be limiting progress in this area of research lies in limited specificity, given that the DBD has high sequence homology among all members of the nuclear receptor family

Human germline mutations in glutarate metabolism highlight its fundamental biological role, with loss of function mutations in glutaryl-CoA dehydrogenase (GCDH) resulting in glutarate accumulation and glutaric aciduria type 1 (GA1)a rare autosomal disorder characterized by dystonia, developmental delay and often death in early childhood 10

Further study confirmed the findings and showed the effects were superior compared to GLP-1 receptor agonist [42]

NO is intricately involved in both vascular homeostasis and inflammatory processes ( In conclusion, our results provide a compelling foundation for the use of targeted, ROS-responsive GO@GSH-FA nanoparticles as a therapeutic platform in cerebral I/R injury