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Despite being truncated, sermorelin retains full biological activity at the GHRH receptor, meaning it produces the same pituitary response as endogenous GHRH (2)

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Although formulation strategies have shifted away from single-component enhancers, towards rationally designed multi-excipient systems, improvements in oral bioavailability have remained incremental

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For instance, some studies aimed at reducing IGF-I levels or inhibiting the activity of IGF-IR and the downstream signaling pathways